180 capsules Tauroursodeoxycholic acid 85mg + Polyenylphosphatidylcholine 200mg + B6 3mg + Chromium (as picolinate) 40 mcg + Chromium (as polynicotinate) 40 mcg
Formula for Ultimate Liver Protection
There are many types of liver injury, but only one is normally
associated with the use of oral androgens – cholestasis. This condition
is defined as a failure of normal bile to reach the duodenum, which may
be due to a number of different pathological states between the
hepatocyte and the ampulla of Vater. When one takes oral androgens
(typically methylated at C17a) the physical structure of the hepatocyte
is altered — microfilaments and canaliculi become less contractile.
Disruptions in the canalicular bile salt export pump may also occur.
This leads to impaired bile flow and the retention of highly cytotoxic
hydrophobic bile salts. At low concentrations, these retained bile salts
cause apoptosis; at higher concentrations, necrosis and severe liver
damage.This is where Aegis comes into the picture. It was designed with
users of oral androgens in mind, and brings together the best
anti-cholestatic ingredients available.
* Can prevent apoptosis during cholestasis. Toxic bile acids produce
apoptosis Via fasand TRAIL- death receptor mediated pathways. Both are,
to some degree, dependent on the translocation of the ‘bax’ pro-apoptoic
molecule from the cytosol of hepatocytes to the cell mitochondria.
TUDCA prevents bax translocation, strongly stabilizes mitochondrial
membranes, and activates the MAPK pro-survival pathway in hepatocytes.
(1) These effects protect hepatocytes from bax-related apoptosis.
* Is a hydrophilic bile acid, and its presence markedly shifts the bile
pool towards hydrophilicity, which, to some extent, detoxifies it. When
used consistently, especially at pharmacological doses, TUDCA (along
with UDCA) eventually becomes the predominant bile acid in the liver and
in general circulation. (2)
* Directly stimulates bile secretion via modulating cellular signalling
pathways in hepatocytes, such as ERK, src, PKC and others. These
signalling pathways generally phosphorylate, or activate, the bile salt
export pump (BSEP) and other processes involved in bile
export/secretion. (For example, PKC-alpha-mediated secretion of HCO3-.)
(3, 4, 5)
* Stabilizes cellular membranes and dilates bile canaliculi. This former
effect has been shown to protect human cells from hydrophobic bile salt
induced apoptosis (6), and the latter may serve to counteract the
reduction in contractility seen in androgeninduced cholestasis. (7)
* Oral androgen administration may decrease hepatic Na+, K+-ATPase,
Ca2+, Mg2+-ATPase and F-actin levels — all of which may be restored, and
even raised, by polyenylphosphatidylcholine administration. (8)
* Is secreted into bile by hepatocytes, where it serves as a major
component of the micelles in which bile acids are emulsified. Increased
levels of biliary phosphatidylcholine reduces the cytotoxicity of bile
acids, whereas phosphatidylcholine-secretion impairment (as is often
seen in ABCB4 disease) is characterized by extremely severe cholestatic
liver disease. (9)
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Only adults 21 years of age or older that are healthy and have
consulted a physician may purchase and use any of our items.